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Posted by on Nov 26, 2012 in Science |

Create method for making pyramidal cages for living cells

Create method for making pyramidal cages for living cells

A team of researchers from the University of Twente in the Netherlands succeeded in developing a method for making microscopic pyramids that are able to act as a cage for a living cell. This would allow better observing the in their natural environment in three dimensions, in contrast to the flat surfaces of a petri dish.

The method, called “lithography corners’ – is to deposit nitrides in a three-dimensional mold silicone. Subsequently, when the material is removed, small amounts remain in the corners of the mold allowing to construct forms of sharp edges.

Like the pyramids are very close and have openings in their sides, this allows caged cells interact with each other as if they did naturally. “The 3D surface shape mimics how certain cells in tissues behave. Everything in our body is three-dimensional, “said Aart van Apeldoorn, one of the researchers.

3D Nanofabrication of Fluidic Components by Corner Lithography (Wiley)
Living cells captured in pyramid cages (NewScientist)

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